What OS are you using. First as an administrator use your system disk check program make sure you disk is in good shape. Free up as much space as you can on you boot disk use your system disk clean up program to delete temp file. Make sure there is lots of free disk space. Then login as the non administrator user start Photoshop and press and hold Ctrl|CMD+Atl|Option+Shift as soon as you start Photoshop. If done in time Photoshop should prompt you asking if you want your preferences deleted. Reply Yes, Photoshop should then start up and work..
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