Try printing to the Adobe PDF printer with Print-to-File selected. Then open the file in Distiller to get a PDF. That should demonstrate the basic issues. If you get the file in the first step, then Distiller should show you any errors in the creation process. If the process works, then check for the status of AcroTray running in the background. I was originally going to suggest AcroTray issues until you said you get PDFs from other applications.
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